Individuals or couples known to carry a balanced chromosomal translocation or inversion.
Structural Rearrangements (PGT-SR)
A specialised genetic test used to screen embryos for chromosomal rearrangements, such as translocations or inversions, that can affect fertility or increase the risk of miscarriage. PGT-SR helps identify embryos with balanced chromosome structures, supporting safer and more successful pregnancies.
What is Structural Rearrangements (PGT-SR)?
Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR) is a specialized genetic test performed on embryos created through In Vitro Fertilization (IVF) to identify structural
chromosomal abnormalities such as translocations, deletions, or inversions. These rearrangements can lead to recurrent pregnancy loss, implantation failure, or genetic disorders in offspring.
At Genesis Athens, PGT-SR is conducted in collaboration with expert embryologists and genetic specialists to ensure accurate results and optimal embryo selection. By analyzing each embryo before transfer, this technique helps improve implantation success and reduce miscarriage risks.
Who is Structural Rearrangements (PGT-SR) for?
Patients with a history of repeated miscarriage or implantation failure.
Couples with a family history of chromosomal abnormalities.
Treatment steps
Your step-by-step guide to Structural Rearrangements (PGT-SR)
Every treatment at Genesis follows a structured, personalised process designed to support you medically and emotionally at every stage. From the first consultation to post-treatment care, we are here to guide you with clarity, expertise, and compassion. While each treatment has its own clinical steps, the journey always begins with understanding your individual needs and building a plan that gives you the best possible chance of success.
Structural Rearrangements (PGT-SR)
You will meet with a fertility doctor and genetic counsellor to review your personal and family history. A genetic blood test may be performed to confirm the presence of a chromosomal rearrangement.
An IVF cycle is performed to retrieve eggs, fertilise them in the laboratory, and allow embryos to develop to the blastocyst stage for testing.
A few cells are taken from each embryo and sent to a certified genetics lab for detailed chromosomal analysis. Embryos are frozen during this period.
The doctor reviews the results with you and helps choose the embryo(s) that are chromosomally balanced or normal for transfer.
A healthy embryo is thawed and transferred to the uterus in a gentle, ultrasound-guided procedure.
A blood test is performed approximately two weeks later to confirm whether implantation has occurred.
Patient Journey
Your pathway to parenthood with us
At Genesis, every fertility journey is deeply personal. We understand the emotional and medical challenges involved, which is why our team is here to support you with care, expertise, and understanding — every step of the way.
Get in touch
Call our team and let us guide you through the first steps of your fertility journey with kindness, clarity, and full support.
Book a consultation
Meet with a specialist to review your results and receive clear, personalised guidance on your next steps.
Define your treatment
Your fertility plan will be built around your needs, giving you the best chance of success with care that truly fits you.
Every journey is different
No two paths are alike. We keep you informed and supported with answers and care tailored to your experience.
F.A.Q.
Structural Rearrangements (PGT-SR) F.A.Q.
We know that starting fertility treatment often comes with many questions — about the process, the risks, and what to expect. In this section, we address some of the most common concerns to help you feel more confident and informed.
If you do not see your question here, our team is always available to provide further guidance, personalised to your specific situation.
It is a genetic change in the structure of chromosomes, such as a translocation or inversion, that can lead to the creation of embryos with unbalanced genetic material.
If you or your partner carry a known structural rearrangement or have a history of recurrent miscarriage or abnormal embryos, your doctor may recommend this test.
No. PGT-A screens for numerical abnormalities (extra or missing chromosomes), while PGT-SR specifically detects structural rearrangements affecting chromosome arrangement.
Not usually. Many individuals with balanced translocations are healthy but may experience fertility issues due to the creation of embryos with unbalanced chromosomes.
No. Embryo biopsies are performed carefully by experienced embryologists, and the embryos are safely frozen while testing is completed.
PGT-SR significantly reduces the risk of transferring embryos with unbalanced chromosomes, but it does not screen for all possible genetic conditions.
Get in touch with an expert
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Structural Rearrangements (PGT-SR)
If you have any questions about Structural Rearrangements (PGT-SR) or if you’re concerned about your fertility, our friendly patient support team is here to provide the support and guidance you need.
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