Monogenic Disorders (PGT-M)

A highly specialised genetic screening used to detect single-gene disorders in embryos before transfer. PGT-M is recommended for individuals or couples who carry or are at risk of passing on inherited genetic conditions, offering the possibility of a healthy pregnancy and peace of mind.

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Preimplantation genetic testing for monogenic disorders (PGT-M) at Genesis Athens.

What is Monogenic Disorders (PGT-M)?

Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) is a specialized procedure used to detect inherited single-gene mutations in embryos created through In Vitro Fertilization (IVF). It is recommended for couples with a known risk of passing on a genetic disease to their children.

The process involves performing an Embryo Biopsy at the blastocyst stage, where a few cells are analyzed without affecting the embryo’s development. The goal is to select embryos free of the identified mutation before transfer, ensuring a healthy pregnancy.

At Genesis Athens, PGT-M testing is conducted by certified genetic laboratories using advanced molecular techniques that ensure accuracy, traceability, and full compliance with international medical and ethical standards.

Who is Monogenic Disorders (PGT-M) for?

Individual considering genetic testing due to being a carrier of a monogenic disorder.

Individuals or couples who are known carriers of a monogenic (single-gene) disorder.

Family with a history of inherited genetic conditions considering PGT-M testing.

Families with a history of inherited genetic conditions.

Parent holding a child previously affected by a genetic disorder, considering PGT-M testing.

Patients who have previously had a child affected by a genetic disorder.

Treatment steps

Your step-by-step guide to Monogenic Disorders (PGT-M)

Every treatment at Genesis follows a structured, personalised process designed to support you medically and emotionally at every stage. From the first consultation to post-treatment care, we are here to guide you with clarity, expertise, and compassion. While each treatment has its own clinical steps, the journey always begins with understanding your individual needs and building a plan that gives you the best possible chance of success.

Monogenic Disorders (PGT-M)

You will meet with a fertility specialist and genetic counsellor to review your medical and family history, confirm the condition to be tested, and plan your personalised treatment pathway.

You will undergo an IVF cycle to retrieve eggs and fertilise them in the lab. Embryos are cultured to the blastocyst stage for biopsy.

A few cells are carefully removed from each embryo and sent to a specialised lab to test for the specific gene mutation(s). Embryos are frozen while awaiting results.

Once results are available, your doctor will review them with you and help select an embryo that does not carry the targeted genetic disorder for transfer.

The selected embryo is thawed and transferred to the uterus in a straightforward, gentle procedure guided by ultrasound.

A blood test is performed approximately two weeks after transfer to confirm pregnancy.

Patient Journey

Your pathway to parenthood with us

At Genesis, every fertility journey is deeply personal. We understand the emotional and medical challenges involved, which is why our team is here to support you with care, expertise, and understanding — every step of the way.

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Call our team and let us guide you through the first steps of your fertility journey with kindness, clarity, and full support.

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Meet with a specialist to review your results and receive clear, personalised guidance on your next steps.

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Your fertility plan will be built around your needs, giving you the best chance of success with care that truly fits you.

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No two paths are alike. We keep you informed and supported with answers and care tailored to your experience.

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F.A.Q.

Monogenic Disorders (PGT-M) F.A.Q.

We know that starting fertility treatment often comes with many questions — about the process, the risks, and what to expect. In this section, we address some of the most common concerns to help you feel more confident and informed.

If you do not see your question here, our team is always available to provide further guidance, personalised to your specific situation.

PGT-M can detect a wide range of inherited disorders caused by a single faulty gene, including cystic fibrosis, thalassemia, Tay-Sachs disease, and Huntington’s disease. The test is specific to the condition being screened.

No. The biopsy is performed by skilled embryologists using advanced techniques. The embryo remains viable and is safely frozen while results are processed.

Not always. Even if only one partner is a carrier of a dominant disorder, PGT-M may be necessary. In other cases, both partners may be carriers of a recessive condition.

PGT-M is highly accurate when designed for a known genetic mutation. It requires prior genetic testing of the parents to develop a customised probe for analysis.

Yes. PGT-M is often performed alongside PGT-A (chromosome screening) to select embryos that are both chromosomally normal and free of the targeted disorder.

Yes. Genetic counselling is essential to confirm the diagnosis, review family history, and design the correct testing protocol for your embryos.

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Monogenic Disorders (PGT-M)

If you have any questions about Monogenic Disorders (PGT-M) or if you’re concerned about your fertility, our friendly patient support team is here to provide the support and guidance you need.

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Success Stories

Results that bring happiness to birth

Behind every success is a unique story of hope, strength, and care. At Genesis Athens, we are honoured to be part of the journeys that lead to new beginnings. From first consultations to the moment a child is born, our team stands beside each individual and couple with expertise, empathy, and dedication. Discover real experiences from patients who turned their dreams into reality — guided by the care, science, and support they found at Genesis.